After achieving an undefeated regular season in 2011, the Panthers were hoping for a repeat as Class A champions, but fell short as their 11-5 pre-tournament record placed them third in the tournament. After beating Gates Chili in the quarter final round, Pittsford lost to Penfield in the semifinals and finished as seeded and with an 12-6 final record. With losses to Fairport and Penfield during the regular season the Panthers finished third in the highly competitive Monroe County D1 league (3-2). A highlight for the Panthers was the mid-season winning run of nine games in a row, including a double overtime win against Thomas.

Six players had over twenty points during the season. Senior midfielder Corey Parke led the team in goal production and points with 39g-23a (62 pts). Junior attackman Albie DiPasquale led in assists with 29g-32a. Senior middie Nino DiPasquale added 14g-7a, senior attackman Jack Lauroesch had 22g-6a, sophomore attackman Stephen Quinzi added 23g-9a and junior middie Steven Ricci had 12g-9a. The six players scored 225 of the 286 points scored by Pittsford. Thirteen other players added the remaining sixty-one points. Junior goalie Kyle Lake had most of the goal time for Pittsford and made 96 saves (54%). Senior Luke Loveys also had a good amount of time and made 40 saves (53%). Out front, senior Derek Jamison, sophomore Nick Panara and junior Cameron Pincus led the long sticks along with senior Derek Jamison who led the team in take aways with eight. Senior face off man Matt Barbaccia took the majority of the draws and won 113 (58%) for Pittsford.

Albie DiPasquale, Parke and Jamison were named to the Monroe County D1 first team. Senior middie Tyler Aycock and Panara were named to the second team. Ricci was named to the Class A All-tournament team. Parke made the Section Five All-Section first team and Albie DiPasquale was named to the second team. Parke also was selected to the D&C top 16 list.

Corey Parke was selected as a USLacrosse All American. The USLacrosse "Bob Scott Award", given to a senior of outstanding character, good academic standing and one who demonstrates good sportsmanship and safe play was awarded to defenseman Kevin Sanna, who was injured pre-season, but still worked with his team.

Nine seniors announced their intention to continue to play at the college level. Aycock selected Albany, Jamison and Romas chose Mercyhurst, Lauroesch chose Williams, defenseman Billy Malone planned to attend King's College, Parke selected Georgetown, Sanna went to Hartford, defenseman Ryan Stahlecker selected Maritime and midfielder Marc Weyl was off to Oswego.